ABSTRACT   Purpose: We hypothesized that Kaltenborn manual therapy induces hypoalgesia and increases strength in secondary carpometacarpal osteoarthritis (CMC OA). Method: Twenty-nine patients with secondary CMC OA (70–90 years old) were randomized into Kaltenborn manual therapy and sham groups. All patients were females. This study was designed as a double-blind, randomized controlled trial (RCT). [...]